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At least 120 people were reportedly killed in random bombings in the Dar-Salam area of the Sudanese city of Omdurman, across the Nile from the capital Khartoum, according to a local volunteer network.
The Ombada Emergency Response Room said the death toll was provisional, suggesting the death toll could rise.
Rescuers say medical supplies are running low as health workers struggle to treat large numbers of people injured in the bombings.
Sudan’s civil war, now 21 months old, has killed tens of thousands, uprooted more than 12 million and pushed the country to the brink of famine in what the UN describes as one of the world’s worst humanitarian disasters.
It began last year after the army leadership and a paramilitary force, the Rapid Support Forces (RSF), fell out over the future direction of the country.
The Ombada Emergency Response Room did not specify who was behind the attack in Omdurman.
Volunteers and emergency response teams have faced challenges accessing some areas due to ongoing fighting.
Most of Omdurman is under army control, while the RSF holds the capital and part of the greater Khartoum area.
In recent weeks, the army has stepped up its offensive in Omdurman in a bid to regain control. It is reported that the army has captured three areas and confiscated the weapons left by the paramilitary forces.
RSF fighters are retreating from positions in both districts. Residents on both sides of the Nile have reported shelling along the river, with bombs and shrapnel regularly hitting homes and civilians.
“The area has been devastated by prolonged fighting leaving residents exposed to street bullets and shrapnel attacking houses,” said the Ombada Emergency Response Room.
Both sides have been accused of indiscriminately targeting civilians, including health workers, and residential areas.
The recent unrest has forced emergency response rooms, which support local communities amid the ongoing conflict, to close several health centers that provide medical services to thousands of residents.